San Francisco 49ers Defeat Indianapolis Colts 48-27

By Stas Bedunkevich December 23, 2025

The San Francisco 49ers beat the Indianapolis Colts 48-27 in a Monday night game. 49ers quarterback Brock Purdy threw for a career-high five touchdown passes, while Colts quarterback Philip Rivers also had a strong performance.

San Francisco 49ers Defeat Indianapolis Colts 48-27 Story coverage

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Reference: https://fox-vector.syndichain.com/stories/019b4a5f-0255-017b-719f-2bae620a4f70

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